| Cause of Death | Annual Deaths | Infectious Agents |
| Lower Respiratory Infection | 3,700,000 | bacteria, viruses, protozoa, fungi |
| Tuberculosis | 2,900,000 | bacteria |
| Diarrheal Diseases | 2,500,000 | bacteria, viruses, protozoa |
| AIDS | 2,300,000 | virus, secondary agents (bacteria, protozoa) |
| Malaria | 1,500,000 - 2,700,000 | protozoa |
| Hepatitis (all types) | 1,000,000 - 2,000,000 | viruses |
| Measles | 220,000 | virus |
| Meningitis (bacterial) | 200,000 | bacteria |
| Shistosomiasis | 200,000 | worm |
| Pertussis (whooping cough) | 100,000 | bacterium |
| Amebiasis | 40,000 - 100,000 | protozoa |
| Hookworm | 50,000 - 60,000 | worm |
| Rabies | 35,000 | virus |
| Yellow Fever | 30,000 | virus |
| Sleeping Sickness | 20,000 | protozoan |